Educational Background
2004–2009: Ph.D. in Science, The University of Hong Kong
2000–2004: Bachelor of Science, Peking University
Work Experience
2016–Present: Specially Appointed Researcher, Peking University Shenzhen Graduate School
2012–2016: Postdoctoral Fellow, Rockefeller University, USA
2010–2011: Assistant Researcher, The University of Hong Kong
Research Interests
Our research primarily focuses on the interdisciplinary field of chemical biology, integrating chemistry and biology. We aim to develop and utilize small-molecule chemical tools—such as fluorescent probes, bioorthogonal chemical probes, and photo-crosslinking probes—to study the biological roles of active small molecules in living systems, investigate protein post-translational modifications and interactions, elucidate their relationships with disease pathogenesis, and ultimately provide new insights for disease treatment. We employ a multidisciplinary collaborative approach, including organic synthesis, biochemistry, cell biology, and proteomics, to achieve our research goals. We welcome graduate students and research assistants from diverse academic backgrounds to join us!
Representative Achievements (Last 5 Years)
1) Yuqing Zhang#, Yimeng Du#, Manjia Li, Dong Zhang, Zheng Xiang,Tao Peng*, Activity-Based Genetically Encoded Fluorescent and Luminescent Probes for Detecting Formaldehyde in Living Cells.Angew. Chem. Int. Ed.2020,59(38), 16352-16356.
2) Yimeng Du#,Yuqing Zhang#, Meirong Huang#, Shushu Wang, Jianzheng Wang, Kongke Liao, Xiaojun Wu, Qiang Zhou, Xinhao Zhang, Yun-Dong Wu*,Tao Peng*, Systematic Investigation of the Aza-Cope Reaction for Fluorescence Imaging of Formaldehyde In Vitro and In Vivo.Chem. Sci.2021,12(41), 13857-13869.
3) Yanan Sun#, Yanchi Chen#,Tao Peng*, A Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation.Chem. Sci.,2022,13(20), 6019-6027.
4) Yanan Sun#, Yanchi Chen#, Yaxin Xu, Yuqing Zhang, Minghao Lu, Manjia Li, Liyan Zhou,Tao Peng*, Genetic Encoding of ε-N-L-Lactyllysine for Detecting Delactylase Activity in Living Cells.Chem. Commun.,2022, 58 (61), 8544-8547
