Educational Background
2002-2007 doctor of science, Peking University
1998-2002 Bachelor of science, Peking University
Work Experience
2016- distinguished researcher, Shenzhen Graduate School, Peking University
2014-2015 University of California San Francisco, postdoctoral
2008-2014 post doctoral fellow, Salk Institute, USA
Research Interests
The research interests of our research group mainly include: 1. Gene coding amplification and its application in biological research; 2. Biocatalysis and metabolic engineering to achieve semi synthesis and diverse synthesis of natural products; 3. Research on small molecule inhibitors targeting important drug targets.
Representative Achievements
1) Hua-Qi Wang, Shu-Bin Mou, Wen Xiao, Huan Zhou, Xu-Dong Hou, Su-Jing Wang, Qian Wang, Jiali Gao,* Zhiyi Wei,* Lijun Liu,*Zheng Xiang*, Structural Basis for the Friedel–Crafts Alkylation in Cylindrocyclophane Biosynthesis.ACS Catal.2022,12, 2108–2117.
2) Shu-Bin Mou,#Wen Xiao,#Hua-Qi Wang, Su-Jing Wang andZheng Xiang*, Syntheses of Epoxyguaiane Sesquiterpenes (–)-Englerin A, (–)-Oxyphyllol, (+)-Orientalol E, and (+)-Orientalol F: A Synthetic Biology Approach.Org. Lett.2020,22, 1976–1979.
3) Shu-Bin Mou, Wen Xiao, Hua-Qi Wang, Kai-Yue Chen andZheng Xiang*, Syntheses of the Carotane-type Terpenoids (+)-Schisanwilsonene A and (+)-Tormesol via a Two-Stage Approach.Org. Lett.2021,23, 400–404.
4) Zheng Xiang,#Haiyan Ren,#Ying S. Hu, Irene Coin, Jing Wei, Hu Cang and Lei Wang*. Add an unnatural covalent bond to proteins through proximity-enhanced bioreactivity.Nat. Methods.2013,10, 885–888.
5) Zheng Xiang, Vanessa K. Lacey, Haiyan Ren, Jing Xu, David J. Burban, Patricia A. Jennings and Lei Wang*. Proximity Enabled Protein Crosslinking via Genetically Encoding Haloalkane Unnatural Amino Acids.Angew. Chem. Int. Ed.2014,53, 2190–2193.
