Educational Background
2013–2018: Ph.D in Chemistry (Chemical Biology), Peking University
2009–2013: Bachelor of Science in Chemistry, Xiamen University
Work Experience
2022–Present: Assistant Professor, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
2022–Present: Distinguished Researcher, Institute of Chemical Biology, Shenzhen Bay Laboratory
2018–2021: Postdoctoral Fellow, Department of Chemistry and Chemical Biology, Harvard University
Awards and Honors
2023: March 8th Red Flag Pacesetter, Guangming District, Shenzhen
2022: Excellent Young Scientists Fund, National Natural Science Foundation of China
2018: Outstanding Graduate, Peking University
2017: National Scholarship for Doctoral Candidates, Peking University
2017: Outstanding Research Award, Peking University
2017: "Chemistry Star" Award and Best Performance Award, College of Chemistry and Molecular Engineering, Peking University
2016: Tang Aoqing Chemistry Scholarship
2016: Meritorious Student Award, Peking University
2015: Academic Scholarship, Peking University
2013–2015: President’s Scholarship for Doctoral Candidates, Peking University
Research Interests
The research group focuses on the cutting-edge interdisciplinary field of chemical biology, dedicated to the evolution and engineering of functionalized proteins, the development and application of tools for regulating protein post-translational modifications, and the characterization of cell surface modifications and interactions. By leveraging protein-based chemical biology tools alongside methodologies such as proteomics, the group aims to elucidate the functions of protein post-translational modifications—including glycosylation—in various physiological processes. This work seeks to provide novel insights for developing new diagnostic and therapeutic strategies.
Representative Publications
1) Ge, Y.;Ramirez, D. H.; Yang, B.; D’Souza, A. K.; Aonbangkhen, C.; Wong, S.; Woo, C. M.*, Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase. Nature Chemical Biology2021, 17 (5), 593-600.
2) Ge, Y.#;Chen, L.#; Liu, S.; Zhao, J.; Zhang, H.; Chen, P. R.*, Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions. Journal of the American Chemical Society2019, 141 (5), 1833-1837.
3) Chen, Y.#; Wan, R.#; Zou, Z.#; Lao, L.; Shao, G.; Zheng, Y.; Tang, L.; Yuan, Y.;Ge, Y.*;He, C.*; Lin, S.*, O-GlcNAcylation determines the biological function of YTHDF proteins. Nature Cell Biology2023, accepted.
4) Liu, Y.#;Ge, Y.#; Zeng, R.#; Ngai, W. S.; Fan, X.*; Chen, P. R.*, Proximity Chemistry in Living Systems. CCS Chemistry2023, 5 (4), 802-813.
5) Ge, Y.*; Lu, H.; Yang, B.; Woo, C. M.*, Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells. ACS Chemical Biology2023, 18 (1), 193-201.
6) Ge, Y.#;Fan, X.#; Chen, P. R.*, A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chemical Science2016, 7 (12), 7055-7060.
7) Ge, Y.;Woo, C. M.*, Writing and erasing O-GlcNAc from target proteins in cells. Biochemical Society Transactions2021, 49 (6), 2891-2901.
Patents
1) Woo, C. M.;Ge, Y., “Small-molecule-activated glycan modifying enzymes and uses thereof”, US
provisional application, WGS H0824.70418US00.
2) Woo, C. M.;Ge, Y.;Ramirez, D. H., “Nanobody-OGA Fusions and Uses Thereof”. International
Application WO2022076329A1. 04/14/2022.
3) Chen Peng; Chen Long; Ge Yun; Liu Shibo; Enzymes and methods for labeling cell membrane surfaces and studying cell-cell interactions, 2021-7-9, China, ZL 2019 1 0067616.3.
4) Yang Chaoyong; Zhang Huimin; Song Yanling; Zou Yuan; Zhu Zhi; Ge Yun; Tian Zhongqun; DNA base analog containing a photocrosslinking diazirine group and its synthesis method, 2015-09-23, China, ZL201310383256.0.
