Educational Background
1989-1993 Queen's University, doctor
1983-1986 East China University of science and technology, master
1979-1983 East China University of science and technology, bachelor
Work Experience
2015.9-Present Shenzhen Graduate School of Peking University
2001-2015.8 Hong Kong Polytechnic University
1998-2001 University of Hong Kong
1994-1998 University of Nottingham, postdoctoral
1993-1994 Queen's University, postdoctoral
Awards and Honors
2014 Hu Xiaoyu Memorial Award
2012 Wuxi apptec Life Chemistry Research Award
2012 Asia core program lecture Award (To deliver lectures in Japan)
2012 Asia core program lecture Award (To deliver lectures in Beijing)
1994－1998 ROPA Fellowship (Engineering and Physical Sciences Research Council, U.K.)
1991 Prize Winner of "The Pfizer Organic Chemistry Poster Symposium"
Research Interests
Our research group focuses on medicinal chemistry and chemical biology. Our laboratory has been committed to developing small molecule compounds with medicinal value by means of chemical synthesis, including two main research directions:
1) Total synthesis of natural products and their analogues with significant structural and bioactive characteristics. In the past half century, natural product molecules have shown great value in the development of pharmaceutical industry. About 60% of anticancer drugs in the world originate from natural organisms. Thanks to the long biological evolution and biodiversity of nature, the endless natural products with different structures have become the direct driving force for the development of tumor clinical treatment. The chemical synthesis of natural product molecules and their analogues plays an important role in the discovery and development of drug molecules. Synthetic chemistry can not only further verify the molecular structure of natural products, but also make it possible to further optimize and derive the strategy based on natural product molecular lead compounds. A variety of natural product analogues and related structure-activity relationships can be obtained by synthetic chemistry, which is a prerequisite for drug research and development. Many research projects of this research group are to train graduate students in synthetic strategies and techniques / skills through the total synthesis of complex natural products, and study the mechanism of biological activity of natural products. The research group has completed the total synthesis of natural product molecules:
2)Design and synthesis of new small molecule bioprobes and drugs in the second research direction, our research group mainly carried out the research of using rationally designed molecular probes to solve the problems in cancer biology. In the vast majority of biological processes, protein-protein interactions play a vital role, and the regulation of protein-protein interactions has naturally become an effective means of disease treatment. Using small molecules to regulate specific protein-protein interactions is gaining more and more attention and development. This method plays a very important role in explaining life phenomena and developing new drugs. The project team works closely with the laboratory of Biochemistry and theoretical computational chemistry to design and synthesize small molecule compounds and peptide analogues to inhibit the degradation of important anticancer genes p27 and p53, and regulate the histone methylation process in vivo to achieve the goal of inhibiting the occurrence and development of cancer.
Representative Achievements (Last 5 years)
1) Junya Takino, Akari Kotani, Taro Ozaki, Wenquan Peng, Jie Yu, Yian Guo, Susumu Mochizuki, Kazuya Akimitsu, Masaru Hashimoto, Tao Ye,*Atsushi Minami,*Hideaki Oikawa*Biochemistry-Guided Prediction of the Absolute Configuration of Fungal Reduced Polyketides,Angew. Chem. Int. Ed.2021,60, 23403–11
2) Xuelei Jia, Dr. Honghui Lei, Feipeng Han, Tao Zhang, Ying Chen, Zhengshuang Xu, Pratanphorn Nakliang, Sun Choi, Yian Guo,Tao Ye*Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2-Catalyzed Intramolecular [3+2] CycloadditionAngew. Chem. Int. Ed.2020,59, 12832-6
3) Junyang Liu, Ying Chen, Hendrik Luesch, Tao Ye* Total Synthesis ofdes-Thiomethyllooekeyolide AOrg. Lett.2022,24, 7260−4
4) Mingze Yang, Wenquan Peng, Yian Guo, and Tao Ye* Total Synthesis of Dysoxylactam AOrg. Lett.2020,22, 1776-9;
5) Jie Yu, Mingze Yang, Yian Guo, and Tao Ye*Total Synthesis of Psymberin (Irciniastatin A)Org. Lett.2019,21, 3670-3;
6) Yian Guo, Jingjing Zhou, Bowen Gao, Meng Zhao, Jia-Lei Yan, Zhengshuang Xu, Sun Choi, Tao Ye*Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction As a Key StepOrg. Lett.2019,21, 5471-4
