Educational Background
2009-2016 PhD, Institute of molecular medicine, Peking University
2005-2009 Bachelor,College of Life and Environmental Sciences, Minzu University of China
Work Experience
2021-now tenure track assistant professor, Shenzhen Graduate School, Peking University
2021-now Shenzhen Bay laboratory distinguished researcher
2016-2020 Postdoctoral Fellow of Peking University Tsinghua Life Sciences Joint Center / biomedical frontier Innovation Center
Awards and Honors
1. Scientific research projects and awards:
Excellent youth fund of the National Natural Science Foundation of China
Chief scientist of the national key R & D program young scientist program
Special fund of the National Natural Science Foundation of China
General fund of the National Natural Science Foundation of China
Shenzhen high level talents - National Leading Talents
First prize of Beijing Science and technology award Natural Science Award (co creator)
The world's best paper "best of cell, 2020" by Cell Press
Ten advances in bioinformatics in China
2. Honors:
Shenzhen Youth May 4th Medal
Shenzhen March 8th red flag bearer
Shenzhen may day female pacesetter
Outstanding craftsman of bright Science City
Advanced individual with outstanding contributions to the construction of Guangming Science City
Excellent Postdoctoral Fellow of Peking University Bayer translational medicine center
Excellent Postdoctoral Fellow of Peking University
Excellent Postdoctoral Fellow of Peking University Tsinghua University Joint Center for Life Sciences
Research Interests
The research group is committed to integrating single-cell multi omics analysis of patients and mouse models and functional research in vivo and in vitro, in order to analyze the pathogenesis of tumors and immune related diseases from the molecular and cellular levels, explore the response and resistance mechanisms of immunotherapy, and explore the functions of tumor / treatment response related cells and next-generation targeting strategies.
Representative Achievements（#=equal contribution；*=corresponding author）
1) Zhang L#,Yu X#, Zheng L#, Zhang Y#, Li Y, Fang Q, Gao R, Kang B, Zhang Q, Huang J. Y., Konno H, Guo X, Ye Y, Gao S, Wang S, Hu X, Ren X, Shen Z*, Ouyang W*, Zhang, Z*, Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.Nature, 2018, 564(7735): 268-272.
2) Zhang L#,Li Z#, Skrzypczynska M.K. #, Fang Q, Zhang W, O'Brien S. A., He Y, Wang L, Zhang Q, Kim A, Gao R, Orf J, Wang T, Sawant D, Kang J, Bhatt D, Lu D, Li C-M, Rapaport A, Perez K, Ye Y, Wang S, Hu X, Ren, X, Ouyang W, Shen Z*, Egen J.G.*, Zhang Z*, Yu X*, Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer.Cell, 2020, 181(2): 442-459.
3) Nie H, Lin P, Zhang Y, Wan Y, Li J, Yin C,Zhang L, Single-cell meta-analysis of inflammatory bowel disease with scIBD,Nature Computational Science, 2023, 3: 522-531.
4) Zhang Land Zhang Z, Recharacterizing tumor-infiltrating lymphocytes by single-cell RNA sequencing.Cancer Immunology Research, 2019, 7(7): 1040-1046.
5) Ren X#,Zhang L#,Zhang Y, Li Z, Siemers N, Zhang Z, Insights gained from single-cell analysis of immune cells in the tumor microenvironment,Annual Review of Immunology, 2021, 39: 583-609.
